High Purity 99% CAS IDRA-21 CAS 22503-72-6 CAS NO. 22503-72-6

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IDRA-21 CAS  22503-72-6

name:IDRA 21

CAS :22503-72-6

Molecular formula:C8H9ClN2O2S

molecular weight:232.69

EINECS:1592732-453-0

Melting point 209°C(Solv:aceticacid(64-19-7))

The boiling point 405.1±55.0°C(Predicted)

The density 1.394±0.06g/cm3(Predicted)

Storage conditions  KChemicalbookeepindarkplace,Inertatmosphere,Roomtemperature

solubility  DMSO(Slightly),Methanol(Slightly,Sonicated)

A crystalline solid

IDRA 21 Chemical Properties

Melting point 209 °C(Solv: acetic acid (64-19-7))

Boiling point 405.1±55.0 °C(Predicted)

density 1.394±0.06 g/cm3(Predicted)

storage temp. Keep in dark place,Inert atmosphere,Room temperature

solubility DMSO (Slightly), Methanol (Slightly, Sonicated)

form Solid

pka 9.78±0.40(Predicted)

color Off-White to Pale Yellow

InChIKey VZRNTCHTJRLTMU-UHFFFAOYSA-N

Uses IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).

Uses IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.